https://ideawaza.com/api.php?action=feedcontributions&feedformat=atom&user=172.165.121.156 2026-09-29T18:09:43Z User contributions MediaWiki 1.46.0 https://ideawaza.com/index.php?title=Kr%C3%BCppel&diff=15671 2007-01-06T16:53:53Z

<p>172.165.121.156: </p> <hr /> <div>'''Krüppel''' is a [[gap gene]] which encodes a [[zinc finger]] protein with four tandemly repeated zinc finger domains.[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=OMIM&amp;dopt=Detailed&amp;tmpl=dispomimTemplate&amp;list_uids=165220]<br /> <br /> Krüppel means, literally, &quot;cripple&quot; in German.<br /> <br /> Put into English, it actually controls the development of a zygote early on in its growth, causing a gap in the otherwise [[heterogeneous]] arrangement of cells. It also controls access to several other subsequent genes, imposing order on the developing embryo[http://www.flybase.org/allied-data/lk/interactive-fly/segment/kruppel1.htm] (See Fig. 1 : a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Kruppel (green) Hairy (red) and Giant (in blue)).<br /> <br /> Fig.1 [http://www.bio.davidson.edu/courses/MolBio/fly/embryred.jpeg]<br /> <br /> See also [[Kruppel-like factors]] which have been recently investigated in the heart but are well characterised for their role in carcinogenesis.<br /> [[Category:Genetics]]<br /> <br /> <br /> {{genetics-stub}}<br /> {{science-stub}}</div>

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