Archive:Personalised external aortic root support - Revision history

Idea at 18:48, 29 September 2026

2026-09-29T18:48:50Z

← Older revision		Revision as of 18:48, 29 September 2026
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	~~{{Short description\|Medical procedure for aortic root aneurysms}}~~
	~~{{Use dmy dates\|date=July 2025}}~~
	The '''personalised external aortic root support''' ('''PEARS''') is a medical procedure for [[aortic root]] aneurysms, can be in patients with connective tissue disorders such as [[Marfan syndrome]]. This technique uses a bespoke microporous textile mesh jacket, tailored precisely to the dimensions of a persons aorta, providing an alternative to conventional surgical methods.<ref name="Kenny Austin Conal Personalized External">{{cite journal \|last1=Kenny \|first1=Louise A. \|last2=Austin \|first2=Conal \|last3=Golesworthy \|first3=Tal \|last4=Venugopal \|first4=Prem \|last5=Alphonso \|first5=Nelson \|title=Personalized External Aortic Root Support (PEARS) for Aortic Root Aneurysm \|journal=Operative Techniques in Thoracic and Cardiovascular Surgery \|date=Summer 2021 \|volume=26 \|issue=2 \|pages=290–305 \|doi=10.1053/j.optechstcvs.2021.03.001 \|doi-access=free }}</ref>		The '''personalised external aortic root support''' ('''PEARS''') is a medical procedure for [[aortic root]] aneurysms, can be in patients with connective tissue disorders such as [[Marfan syndrome]]. This technique uses a bespoke microporous textile mesh jacket, tailored precisely to the dimensions of a persons aorta, providing an alternative to conventional surgical methods.<ref name="Kenny Austin Conal Personalized External">{{cite journal \|last1=Kenny \|first1=Louise A. \|last2=Austin \|first2=Conal \|last3=Golesworthy \|first3=Tal \|last4=Venugopal \|first4=Prem \|last5=Alphonso \|first5=Nelson \|title=Personalized External Aortic Root Support (PEARS) for Aortic Root Aneurysm \|journal=Operative Techniques in Thoracic and Cardiovascular Surgery \|date=Summer 2021 \|volume=26 \|issue=2 \|pages=290–305 \|doi=10.1053/j.optechstcvs.2021.03.001 \|doi-access=free }}</ref>

Waza: Remove deletion notice

2026-09-29T07:31:16Z

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	{{Short description\|Medical procedure for aortic root aneurysms}}		{{Short description\|Medical procedure for aortic root aneurysms}}
	{{Use dmy dates\|date=July 2025}}		{{Use dmy dates\|date=July 2025}}
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	The '''personalised external aortic root support''' ('''PEARS''') is a medical procedure for [[aortic root]] aneurysms, can be in patients with connective tissue disorders such as [[Marfan syndrome]]. This technique uses a bespoke microporous textile mesh jacket, tailored precisely to the dimensions of a persons aorta, providing an alternative to conventional surgical methods.<ref name="Kenny Austin Conal Personalized External">{{cite journal \|last1=Kenny \|first1=Louise A. \|last2=Austin \|first2=Conal \|last3=Golesworthy \|first3=Tal \|last4=Venugopal \|first4=Prem \|last5=Alphonso \|first5=Nelson \|title=Personalized External Aortic Root Support (PEARS) for Aortic Root Aneurysm \|journal=Operative Techniques in Thoracic and Cardiovascular Surgery \|date=Summer 2021 \|volume=26 \|issue=2 \|pages=290–305 \|doi=10.1053/j.optechstcvs.2021.03.001 \|doi-access=free }}</ref>		The '''personalised external aortic root support''' ('''PEARS''') is a medical procedure for [[aortic root]] aneurysms, can be in patients with connective tissue disorders such as [[Marfan syndrome]]. This technique uses a bespoke microporous textile mesh jacket, tailored precisely to the dimensions of a persons aorta, providing an alternative to conventional surgical methods.<ref name="Kenny Austin Conal Personalized External">{{cite journal \|last1=Kenny \|first1=Louise A. \|last2=Austin \|first2=Conal \|last3=Golesworthy \|first3=Tal \|last4=Venugopal \|first4=Prem \|last5=Alphonso \|first5=Nelson \|title=Personalized External Aortic Root Support (PEARS) for Aortic Root Aneurysm \|journal=Operative Techniques in Thoracic and Cardiovascular Surgery \|date=Summer 2021 \|volume=26 \|issue=2 \|pages=290–305 \|doi=10.1053/j.optechstcvs.2021.03.001 \|doi-access=free }}</ref>

Waza: 27 revisions imported: Import with full history

2026-09-29T07:24:11Z

27 revisions imported: Import with full history

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wikipedia>Dl2000: rm excess linespacing

2026-09-24T01:27:00Z

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	One of the significant advantages of the PEARS procedure is that it does not require cardiopulmonary bypass, although it has been used occasionally as an adjunct. The aorta is not clamped or opened, so there is no myocardial ischemia. Additionlly, there is no routine requirement for blood products, nor is there a risk of cerebral ischemia or embolus. This makes the procedure less invasive and reduces the recovery time for patients.<ref name="Treasure Pepper Personalised External">{{cite journal \|last1=Treasure \|first1=Tom \|last2=Pepper \|first2=John \|title=Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root \|journal=Diseases \|date=15 January 2015 \|volume=3 \|issue=1 \|pages=2–14 \|doi=10.3390/diseases3010002 \|doi-access=free \|pmid=28943604 \|pmc=5548228 }}</ref>		One of the significant advantages of the PEARS procedure is that it does not require cardiopulmonary bypass, although it has been used occasionally as an adjunct. The aorta is not clamped or opened, so there is no myocardial ischemia. Additionlly, there is no routine requirement for blood products, nor is there a risk of cerebral ischemia or embolus. This makes the procedure less invasive and reduces the recovery time for patients.<ref name="Treasure Pepper Personalised External">{{cite journal \|last1=Treasure \|first1=Tom \|last2=Pepper \|first2=John \|title=Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root \|journal=Diseases \|date=15 January 2015 \|volume=3 \|issue=1 \|pages=2–14 \|doi=10.3390/diseases3010002 \|doi-access=free \|pmid=28943604 \|pmc=5548228 }}</ref>


	==History==		==History==

wikipedia>Dl2000: repair some editing damage; tidy

2026-09-24T01:26:49Z

repair some editing damage; tidy

← Older revision		Revision as of 01:26, 24 September 2026
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	{{Short description\|Medical procedure for aortic root aneurysms}}		{{Short description\|Medical procedure for aortic root aneurysms}}
			{{Use dmy dates\|date=July 2025}}
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	{{Article for deletion/dated\|page=Personalised external aortic root support\|timestamp=20260923162306\|year=2026\|month=September\|day=23\|substed=yes\|help=off}}		{{Article for deletion/dated\|page=Personalised external aortic root support\|timestamp=20260923162306\|year=2026\|month=September\|day=23\|substed=yes\|help=off}}

wikipedia>Tororro at 16:27, 23 September 2026

2026-09-23T16:27:54Z

← Older revision		Revision as of 16:27, 23 September 2026
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	One of the significant advantages of the PEARS procedure is that it does not require cardiopulmonary bypass, although it has been used occasionally as an adjunct. The aorta is not clamped or opened, so there is no myocardial ischemia. Additionlly, there is no routine requirement for blood products, nor is there a risk of cerebral ischemia or embolus. This makes the procedure less invasive and reduces the recovery time for patients.<ref name="Treasure Pepper Personalised External">{{cite journal \|last1=Treasure \|first1=Tom \|last2=Pepper \|first2=John \|title=Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root \|journal=Diseases \|date=15 January 2015 \|volume=3 \|issue=1 \|pages=2–14 \|doi=10.3390/diseases3010002 \|doi-access=free \|pmid=28943604 \|pmc=5548228 }}</ref>		One of the significant advantages of the PEARS procedure is that it does not require cardiopulmonary bypass, although it has been used occasionally as an adjunct. The aorta is not clamped or opened, so there is no myocardial ischemia. Additionlly, there is no routine requirement for blood products, nor is there a risk of cerebral ischemia or embolus. This makes the procedure less invasive and reduces the recovery time for patients.<ref name="Treasure Pepper Personalised External">{{cite journal \|last1=Treasure \|first1=Tom \|last2=Pepper \|first2=John \|title=Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root \|journal=Diseases \|date=15 January 2015 \|volume=3 \|issue=1 \|pages=2–14 \|doi=10.3390/diseases3010002 \|doi-access=free \|pmid=28943604 \|pmc=5548228 }}</ref>

	Clinical outcomes for PEARS have been favrable. In over 200 patient-years of follow up, there have been no untoward events related to the aortic wall or valve after PEARS. When compared with data for either the [[Bentall procedure]] or [[valve-sparing aortic root replacement]], outcomes so far are very favorable for external support.<ref name="Treasure Pepper Personalised External"/>

	==History==		==History==
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	The concept of PEARS was first proposed in 2000 by Tal Golesworthy, an engineer with familial Marfan syndrome and an aortic root aneurysm. Golesworthy, driven by the need for a less invasive treatment option, assembled a [[research and development]] team to bring his idea to fruition. Collaborating with surgeons, the first clinical implementation of PEARS occurred in 2004, with Golesworthy himself being the first patient to undergo the procedure.<ref>{{cite journal \|last1=Treasure \|first1=Tom \|last2=Takkenberg \|first2=Johanna J M \|last3=Golesworthy \|first3=Tal \|last4=Rega \|first4=Filip \|last5=Petrou \|first5=Mario \|last6=Rosendahl \|first6=Ulrich \|last7=Mohiaddin \|first7=Raad \|last8=Rubens \|first8=Michael \|last9=Thornton \|first9=Warren \|last10=Lees \|first10=Belinda \|last11=Pepper \|first11=John \|title=Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1–9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the published results of aortic root replacement \|journal=Heart \|date=15 June 2014 \|volume=100 \|issue=12 \|pages=969–975 \|id={{CORE output\|43293156}} {{ProQuest\|1780732212}} \|doi=10.1136/heartjnl-2013-304913 \|pmid=24395977 \|pmc=4033204 }}</ref>		The concept of PEARS was first proposed in 2000 by Tal Golesworthy, an engineer with familial Marfan syndrome and an aortic root aneurysm. Golesworthy, driven by the need for a less invasive treatment option, assembled a [[research and development]] team to bring his idea to fruition. Collaborating with surgeons, the first clinical implementation of PEARS occurred in 2004, with Golesworthy himself being the first patient to undergo the procedure.<ref>{{cite journal \|last1=Treasure \|first1=Tom \|last2=Takkenberg \|first2=Johanna J M \|last3=Golesworthy \|first3=Tal \|last4=Rega \|first4=Filip \|last5=Petrou \|first5=Mario \|last6=Rosendahl \|first6=Ulrich \|last7=Mohiaddin \|first7=Raad \|last8=Rubens \|first8=Michael \|last9=Thornton \|first9=Warren \|last10=Lees \|first10=Belinda \|last11=Pepper \|first11=John \|title=Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1–9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the published results of aortic root replacement \|journal=Heart \|date=15 June 2014 \|volume=100 \|issue=12 \|pages=969–975 \|id={{CORE output\|43293156}} {{ProQuest\|1780732212}} \|doi=10.1136/heartjnl-2013-304913 \|pmid=24395977 \|pmc=4033204 }}</ref>

	Since its inception, the PEARS procedure has been performed in hospitals, demonstrating its potential as a viable treatment option. The procedure has undergone health technology appraisal by the [[National Institute for Health and Care Excellence]] (NICE)~~, further validating its efficacy and safety~~.<ref name="NICE"/>		Since its inception, the PEARS procedure has been performed in hospitals, demonstrating its potential as a viable treatment option. The procedure has undergone health technology appraisal by the [[National Institute for Health and Care Excellence]] (NICE).<ref name="NICE"/>

	==See also==		==See also==

wikipedia>Dclemens1971: Nominated for deletion; see :Wikipedia:Articles for deletion/Personalised external aortic root support.

2026-09-23T16:23:06Z

Nominated for deletion; see Wikipedia:Articles for deletion/Personalised external aortic root support.

← Older revision		Revision as of 16:23, 23 September 2026
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	{{Short description\|Medical procedure for aortic root aneurysms}}		{{Short description\|Medical procedure for aortic root aneurysms}}

			<!-- Please do not remove or change this AfD message until the discussion has been closed. -->
			{{Article for deletion/dated\|page=Personalised external aortic root support\|timestamp=20260923162306\|year=2026\|month=September\|day=23\|substed=yes\|help=off}}
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	The '''personalised external aortic root support''' ('''PEARS''') is a medical procedure for [[aortic root]] aneurysms, can be in patients with connective tissue disorders such as [[Marfan syndrome]]. This technique uses a bespoke microporous textile mesh jacket, tailored precisely to the dimensions of a persons aorta, providing an alternative to conventional surgical methods.<ref name="Kenny Austin Conal Personalized External">{{cite journal \|last1=Kenny \|first1=Louise A. \|last2=Austin \|first2=Conal \|last3=Golesworthy \|first3=Tal \|last4=Venugopal \|first4=Prem \|last5=Alphonso \|first5=Nelson \|title=Personalized External Aortic Root Support (PEARS) for Aortic Root Aneurysm \|journal=Operative Techniques in Thoracic and Cardiovascular Surgery \|date=Summer 2021 \|volume=26 \|issue=2 \|pages=290–305 \|doi=10.1053/j.optechstcvs.2021.03.001 \|doi-access=free }}</ref>		The '''personalised external aortic root support''' ('''PEARS''') is a medical procedure for [[aortic root]] aneurysms, can be in patients with connective tissue disorders such as [[Marfan syndrome]]. This technique uses a bespoke microporous textile mesh jacket, tailored precisely to the dimensions of a persons aorta, providing an alternative to conventional surgical methods.<ref name="Kenny Austin Conal Personalized External">{{cite journal \|last1=Kenny \|first1=Louise A. \|last2=Austin \|first2=Conal \|last3=Golesworthy \|first3=Tal \|last4=Venugopal \|first4=Prem \|last5=Alphonso \|first5=Nelson \|title=Personalized External Aortic Root Support (PEARS) for Aortic Root Aneurysm \|journal=Operative Techniques in Thoracic and Cardiovascular Surgery \|date=Summer 2021 \|volume=26 \|issue=2 \|pages=290–305 \|doi=10.1053/j.optechstcvs.2021.03.001 \|doi-access=free }}</ref>

wikipedia>Tororro at 16:18, 23 September 2026

2026-09-23T16:18:18Z

← Older revision		Revision as of 16:18, 23 September 2026
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	{{Short description\|Medical procedure for aortic root aneurysms}}		{{Short description\|Medical procedure for aortic root aneurysms}}

	The '''personalised external aortic root support''' ('''PEARS''') is a medical procedure ~~designed to manage~~ [[aortic root]] aneurysms, ~~particularly~~ in patients with connective tissue disorders such as [[Marfan syndrome]]. This technique ~~involves the use of~~ a bespoke microporous textile mesh jacket, tailored precisely to the dimensions of ~~an individual's~~ aorta, providing an alternative to conventional surgical methods.<ref name="Kenny Austin Conal Personalized External">{{cite journal \|last1=Kenny \|first1=Louise A. \|last2=Austin \|first2=Conal \|last3=Golesworthy \|first3=Tal \|last4=Venugopal \|first4=Prem \|last5=Alphonso \|first5=Nelson \|title=Personalized External Aortic Root Support (PEARS) for Aortic Root Aneurysm \|journal=Operative Techniques in Thoracic and Cardiovascular Surgery \|date=Summer 2021 \|volume=26 \|issue=2 \|pages=290–305 \|doi=10.1053/j.optechstcvs.2021.03.001 \|doi-access=free }}</ref>		The '''personalised external aortic root support''' ('''PEARS''') is a medical procedure for [[aortic root]] aneurysms, can be in patients with connective tissue disorders such as [[Marfan syndrome]]. This technique uses a bespoke microporous textile mesh jacket, tailored precisely to the dimensions of a persons aorta, providing an alternative to conventional surgical methods.<ref name="Kenny Austin Conal Personalized External">{{cite journal \|last1=Kenny \|first1=Louise A. \|last2=Austin \|first2=Conal \|last3=Golesworthy \|first3=Tal \|last4=Venugopal \|first4=Prem \|last5=Alphonso \|first5=Nelson \|title=Personalized External Aortic Root Support (PEARS) for Aortic Root Aneurysm \|journal=Operative Techniques in Thoracic and Cardiovascular Surgery \|date=Summer 2021 \|volume=26 \|issue=2 \|pages=290–305 \|doi=10.1053/j.optechstcvs.2021.03.001 \|doi-access=free }}</ref>

	==Medical uses==		==Medical uses==

	PEARS is used to support the aortic root and the ascending aorta in patients with aortic root aneurysms. It is particularly beneficial for ~~patients with~~ connective tissue disorders ~~such as~~ Marfan syndrome, [[Loeys–Dietz syndrome]], or ~~those with a~~ [[bicuspid aortic valve]]. The procedure helps to prevent aortic root expansion and [[aortic dissection]], which can lead to severe complications such as aortic valve regurgitation, rupture, and death.<ref name="BJC">{{cite journal \|last1=Pepper \|first1=J. \|last2=Izgi \|first2=C. \|last3=Golesworthy \|first3=T. J. \|last4=Takkenberg \|first4=J. J. \|last5=Treasure \|first5=T. \|title=Personalised external aortic root support (PEARS) to stabilise an aortic root aneurysm \|journal=British Journal of Cardiology \|date=2020 \|volume=27 \|issue=3 \|page=22 \|doi=10.5837/bjc.2020.022 \|pmid=35747770 \|pmc=9205243 }}</ref><ref name="NICE">{{cite report \|title=Personalised external aortic root support (PEARS) using mesh to prevent aortic root expansion and aortic dissection in people with Marfan syndrome \|publisher=[[National Institute for Health and Care Excellence]] \|date=18 May 2022 \|ID=IPG724 \|url=https://www.nice.org.uk/guidance/ipg724 }}</ref>		PEARS is used to support the aortic root and also for the ascending aorta in patients with aortic root aneurysms. It is particularly beneficial for people that have connective tissue disorders like Marfan syndrome, [[Loeys–Dietz syndrome]], or [[bicuspid aortic valve]]. The procedure helps to prevent aortic root expansion and [[aortic dissection]], which can lead to severe complications such as aortic valve regurgitation, rupture, and death.<ref name="BJC">{{cite journal \|last1=Pepper \|first1=J. \|last2=Izgi \|first2=C. \|last3=Golesworthy \|first3=T. J. \|last4=Takkenberg \|first4=J. J. \|last5=Treasure \|first5=T. \|title=Personalised external aortic root support (PEARS) to stabilise an aortic root aneurysm \|journal=British Journal of Cardiology \|date=2020 \|volume=27 \|issue=3 \|page=22 \|doi=10.5837/bjc.2020.022 \|pmid=35747770 \|pmc=9205243 }}</ref><ref name="NICE">{{cite report \|title=Personalised external aortic root support (PEARS) using mesh to prevent aortic root expansion and aortic dissection in people with Marfan syndrome \|publisher=[[National Institute for Health and Care Excellence]] \|date=18 May 2022 \|ID=IPG724 \|url=https://www.nice.org.uk/guidance/ipg724 }}</ref>

	==Procedure==		==Procedure==

	The PEARS procedure ~~begins with~~ a detailed [[CT scan]] of the patient's aorta ~~to gather precise measurements~~. These measurements are then used with [[computer-aided design]] to create a 3D-printed plastic model of the patient's aorta. This model serves as a template for manufacturing the ExoVasc PEARS implant~~, which~~ is made from a soft and pliable biocompatible textile, ~~typically~~ [[polyethylene terephthalate]].{{fact\|date=July 2025}}		The PEARS procedure relies on a detailed [[CT scan]] of the patient's aorta. These measurements are then used with [[computer-aided design]] to create a 3D-printed plastic model of the patient's aorta. This model serves as a template for manufacturing the ExoVasc PEARS implant. This implant is made from a soft and pliable biocompatible textile, normally [[polyethylene terephthalate]].{{fact\|date=July 2025}}

	The ~~implantation~~ process involves opening the chest through the breastbone and wrapping the mesh around the outside of the aorta at the part closest to the heart. This mesh provides ~~graduated~~ support to the aortic root and ascending aorta, reducing the risk of aortic root expansion and aortic dissection.<ref name="Kenny Austin Conal Personalized External"/><ref name="Exstent">{{cite web \|title=ExoVasc® Personalised External Aortic Root Support \|url=https://exstent.com/exovasc-personalised-external-aortic-root-support/ \|publisher=Exstent \|year=2024}}</ref>		The surgical process involves opening the chest through the breastbone and wrapping the mesh around the outside of the aorta at the part closest to the heart. This mesh provides support to the aortic root and ascending aorta, reducing the risk of aortic root expansion and aortic dissection.<ref name="Kenny Austin Conal Personalized External"/><ref name="Exstent">{{cite web \|title=ExoVasc® Personalised External Aortic Root Support \|url=https://exstent.com/exovasc-personalised-external-aortic-root-support/ \|publisher=Exstent \|year=2024}}</ref>

	===Aortic PEARS===		===Aortic PEARS===

	~~In the aortic PEARS procedure, the ExoVasc~~ PEARS supports the dilated aorta in patients with connective tissue disorders. This ~~procedure~~ is less invasive than traditional surgical options and does not require [[cardiopulmonary bypass]].<ref>{{cite journal \|last1=Treasure \|first1=Tom \|last2=Austin \|first2=Conal \|last3=Kenny \|first3=Louise Amelia \|last4=Pepper \|first4=John \|title=Personalized external aortic root support in aneurysm disease \|journal=Current Opinion in Cardiology \|date=29 August 2022 \|volume=37 \|issue=6 \|pages=454–458 \|doi=10.1097/HCO.0000000000000990 \|pmid=36094493 \|url=https://discovery.ucl.ac.uk/id/eprint/10155983/ }}</ref>		The PEARS procedur supports the dilated aorta in patients with connective tissue disorders. This pocedure is less invasive than traditional surgical options and does not require [[cardiopulmonary bypass]].<ref>{{cite journal \|last1=Treasure \|first1=Tom \|last2=Austin \|first2=Conal \|last3=Kenny \|first3=Louise Amelia \|last4=Pepper \|first4=John \|title=Personalized external aortic root support in aneurysm disease \|journal=Current Opinion in Cardiology \|date=29 August 2022 \|volume=37 \|issue=6 \|pages=454–458 \|doi=10.1097/HCO.0000000000000990 \|pmid=36094493 \|url=https://discovery.ucl.ac.uk/id/eprint/10155983/ }}</ref>

	===Ross-PEARS===		===Ross-PEARS===

	The Ross-PEARS procedure involves replacing a diseased aortic valve with the patient's own healthy pulmonary valve, ~~which is~~ then ~~supported by~~ an ~~ExoVasc PEARS~~. This procedure is particularly useful for patients who require [[aortic valve replacement]] but ~~wish~~ to avoid mechanical valve replacement and the associated need for anticoagulation.<ref>{{cite journal \|last1=Treasure \|first1=Tom \|title=Personalized external aortic root support \|journal=Texas Heart Institute Journal \|date=2013 \|volume=40 \|issue=5 \|pages=549–552 \|pmid=24391317 \|pmc=3853825 }}</ref>		The Ross-PEARS procedure involves replacing a diseased aortic valve with the patient's own healthy pulmonary valve, and then supporting the aorta via an implant. This procedure is particularly useful for patients who require [[aortic valve replacement]] but wsh to avoid mechanical valve replacement and the associated need for anticoagulation.<ref>{{cite journal \|last1=Treasure \|first1=Tom \|title=Personalized external aortic root support \|journal=Texas Heart Institute Journal \|date=2013 \|volume=40 \|issue=5 \|pages=549–552 \|pmid=24391317 \|pmc=3853825 }}</ref>

	==Advantages==		==Advantages==

	One of the significant advantages of the PEARS procedure is that it does not require cardiopulmonary bypass, although it has been used occasionally as an adjunct. The aorta is not clamped or opened, so there is no myocardial ischemia ~~involved~~. ~~Additionally~~, there is no routine requirement for blood products, nor is there a risk of cerebral ischemia or embolus. This makes the procedure less invasive and reduces the recovery time for patients.<ref name="Treasure Pepper Personalised External">{{cite journal \|last1=Treasure \|first1=Tom \|last2=Pepper \|first2=John \|title=Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root \|journal=Diseases \|date=15 January 2015 \|volume=3 \|issue=1 \|pages=2–14 \|doi=10.3390/diseases3010002 \|doi-access=free \|pmid=28943604 \|pmc=5548228 }}</ref>		One of the significant advantages of the PEARS procedure is that it does not require cardiopulmonary bypass, although it has been used occasionally as an adjunct. The aorta is not clamped or opened, so there is no myocardial ischemia. Additionlly, there is no routine requirement for blood products, nor is there a risk of cerebral ischemia or embolus. This makes the procedure less invasive and reduces the recovery time for patients.<ref name="Treasure Pepper Personalised External">{{cite journal \|last1=Treasure \|first1=Tom \|last2=Pepper \|first2=John \|title=Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root \|journal=Diseases \|date=15 January 2015 \|volume=3 \|issue=1 \|pages=2–14 \|doi=10.3390/diseases3010002 \|doi-access=free \|pmid=28943604 \|pmc=5548228 }}</ref>

	Clinical outcomes for PEARS have been ~~favorable~~. In over 200 patient-years of follow up, there have been no untoward events related to the aortic wall or valve after PEARS. When compared with data for either the [[Bentall procedure]] or [[valve-sparing aortic root replacement]], outcomes so far are very favorable for external support.<ref name="Treasure Pepper Personalised External"/>		Clinical outcomes for PEARS have been favrable. In over 200 patient-years of follow up, there have been no untoward events related to the aortic wall or valve after PEARS. When compared with data for either the [[Bentall procedure]] or [[valve-sparing aortic root replacement]], outcomes so far are very favorable for external support.<ref name="Treasure Pepper Personalised External"/>

	==History==		==History==
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	The concept of PEARS was first proposed in 2000 by Tal Golesworthy, an engineer with familial Marfan syndrome and an aortic root aneurysm. Golesworthy, driven by the need for a less invasive treatment option, assembled a [[research and development]] team to bring his idea to fruition. Collaborating with surgeons, the first clinical implementation of PEARS occurred in 2004, with Golesworthy himself being the first patient to undergo the procedure.<ref>{{cite journal \|last1=Treasure \|first1=Tom \|last2=Takkenberg \|first2=Johanna J M \|last3=Golesworthy \|first3=Tal \|last4=Rega \|first4=Filip \|last5=Petrou \|first5=Mario \|last6=Rosendahl \|first6=Ulrich \|last7=Mohiaddin \|first7=Raad \|last8=Rubens \|first8=Michael \|last9=Thornton \|first9=Warren \|last10=Lees \|first10=Belinda \|last11=Pepper \|first11=John \|title=Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1–9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the published results of aortic root replacement \|journal=Heart \|date=15 June 2014 \|volume=100 \|issue=12 \|pages=969–975 \|id={{CORE output\|43293156}} {{ProQuest\|1780732212}} \|doi=10.1136/heartjnl-2013-304913 \|pmid=24395977 \|pmc=4033204 }}</ref>		The concept of PEARS was first proposed in 2000 by Tal Golesworthy, an engineer with familial Marfan syndrome and an aortic root aneurysm. Golesworthy, driven by the need for a less invasive treatment option, assembled a [[research and development]] team to bring his idea to fruition. Collaborating with surgeons, the first clinical implementation of PEARS occurred in 2004, with Golesworthy himself being the first patient to undergo the procedure.<ref>{{cite journal \|last1=Treasure \|first1=Tom \|last2=Takkenberg \|first2=Johanna J M \|last3=Golesworthy \|first3=Tal \|last4=Rega \|first4=Filip \|last5=Petrou \|first5=Mario \|last6=Rosendahl \|first6=Ulrich \|last7=Mohiaddin \|first7=Raad \|last8=Rubens \|first8=Michael \|last9=Thornton \|first9=Warren \|last10=Lees \|first10=Belinda \|last11=Pepper \|first11=John \|title=Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1–9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the published results of aortic root replacement \|journal=Heart \|date=15 June 2014 \|volume=100 \|issue=12 \|pages=969–975 \|id={{CORE output\|43293156}} {{ProQuest\|1780732212}} \|doi=10.1136/heartjnl-2013-304913 \|pmid=24395977 \|pmc=4033204 }}</ref>

	Since its inception, the PEARS procedure has been performed in ~~several~~ hospitals ~~across England~~, demonstrating its potential as a viable treatment option. The procedure has undergone health technology appraisal by the [[National Institute for Health and Care Excellence]] (NICE), further validating its efficacy and safety.<ref name="NICE"/>		Since its inception, the PEARS procedure has been performed in hospitals, demonstrating its potential as a viable treatment option. The procedure has undergone health technology appraisal by the [[National Institute for Health and Care Excellence]] (NICE), further validating its efficacy and safety.<ref name="NICE"/>

	==See also==		==See also==

wikipedia>Tororro: have removed reference to Belgium as per suggestion. This is currently out of date though as it now performed in numerous countries eg australia https://www.svph.org.au/patient-news/northside-turns-25. or singapore https://www.nuhcs.com.sg/heart-information/medical-treatments/personalised-external-aortic-root-support-(pears)

2026-09-23T15:50:42Z

have removed reference to Belgium as per suggestion. This is currently out of date though as it now performed in numerous countries eg australia https://www.svph.org.au/patient-news/northside-turns-25. or singapore https://www.nuhcs.com.sg/heart-information/medical-treatments/personalised-external-aortic-root-support-(pears)

← Older revision		Revision as of 15:50, 23 September 2026
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	{{Short description\|Medical procedure for aortic root aneurysms}}		{{Short description\|Medical procedure for aortic root aneurysms}}
	~~{{Proposed deletion/dated~~
	\|concern = Proposing for deletion per [[WP:LLMPROD]]. Prose contains several [[WP:AISIGNS]]; several sources fail verification (for example, [https://www.nice.org.uk/guidance/htg623/resources/personalised-external-aortic-root-support-pears-using-mesh-to-prevent-aortic-root-expansion-and-aortic-dissection-in-people-with-marfan-syndrome-pdf-1809598463924677 fn 3] doesn't say anything about Belgium and it downplays the efficacy as "adequate" and unclear in the long run); and original version had a [https://doi.org/10.1053%2Fj.optechstcs.2021.03.001 non-existent DOI].
	~~\|timestamp = 20260923145930~~
	~~\|nom = Dclemens1971~~
	~~\|help = off~~
	}}
	~~{{Use dmy dates\|date=July 2025}}~~

	The '''personalised external aortic root support''' ('''PEARS''') is a medical procedure designed to manage [[aortic root]] aneurysms, particularly in patients with connective tissue disorders such as [[Marfan syndrome]]. This technique involves the use of a bespoke microporous textile mesh jacket, tailored precisely to the dimensions of an individual's aorta, providing an alternative to conventional surgical methods.<ref name="Kenny Austin Conal Personalized External">{{cite journal \|last1=Kenny \|first1=Louise A. \|last2=Austin \|first2=Conal \|last3=Golesworthy \|first3=Tal \|last4=Venugopal \|first4=Prem \|last5=Alphonso \|first5=Nelson \|title=Personalized External Aortic Root Support (PEARS) for Aortic Root Aneurysm \|journal=Operative Techniques in Thoracic and Cardiovascular Surgery \|date=Summer 2021 \|volume=26 \|issue=2 \|pages=290–305 \|doi=10.1053/j.optechstcvs.2021.03.001 \|doi-access=free }}</ref>		The '''personalised external aortic root support''' ('''PEARS''') is a medical procedure designed to manage [[aortic root]] aneurysms, particularly in patients with connective tissue disorders such as [[Marfan syndrome]]. This technique involves the use of a bespoke microporous textile mesh jacket, tailored precisely to the dimensions of an individual's aorta, providing an alternative to conventional surgical methods.<ref name="Kenny Austin Conal Personalized External">{{cite journal \|last1=Kenny \|first1=Louise A. \|last2=Austin \|first2=Conal \|last3=Golesworthy \|first3=Tal \|last4=Venugopal \|first4=Prem \|last5=Alphonso \|first5=Nelson \|title=Personalized External Aortic Root Support (PEARS) for Aortic Root Aneurysm \|journal=Operative Techniques in Thoracic and Cardiovascular Surgery \|date=Summer 2021 \|volume=26 \|issue=2 \|pages=290–305 \|doi=10.1053/j.optechstcvs.2021.03.001 \|doi-access=free }}</ref>
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	The concept of PEARS was first proposed in 2000 by Tal Golesworthy, an engineer with familial Marfan syndrome and an aortic root aneurysm. Golesworthy, driven by the need for a less invasive treatment option, assembled a [[research and development]] team to bring his idea to fruition. Collaborating with surgeons, the first clinical implementation of PEARS occurred in 2004, with Golesworthy himself being the first patient to undergo the procedure.<ref>{{cite journal \|last1=Treasure \|first1=Tom \|last2=Takkenberg \|first2=Johanna J M \|last3=Golesworthy \|first3=Tal \|last4=Rega \|first4=Filip \|last5=Petrou \|first5=Mario \|last6=Rosendahl \|first6=Ulrich \|last7=Mohiaddin \|first7=Raad \|last8=Rubens \|first8=Michael \|last9=Thornton \|first9=Warren \|last10=Lees \|first10=Belinda \|last11=Pepper \|first11=John \|title=Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1–9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the published results of aortic root replacement \|journal=Heart \|date=15 June 2014 \|volume=100 \|issue=12 \|pages=969–975 \|id={{CORE output\|43293156}} {{ProQuest\|1780732212}} \|doi=10.1136/heartjnl-2013-304913 \|pmid=24395977 \|pmc=4033204 }}</ref>		The concept of PEARS was first proposed in 2000 by Tal Golesworthy, an engineer with familial Marfan syndrome and an aortic root aneurysm. Golesworthy, driven by the need for a less invasive treatment option, assembled a [[research and development]] team to bring his idea to fruition. Collaborating with surgeons, the first clinical implementation of PEARS occurred in 2004, with Golesworthy himself being the first patient to undergo the procedure.<ref>{{cite journal \|last1=Treasure \|first1=Tom \|last2=Takkenberg \|first2=Johanna J M \|last3=Golesworthy \|first3=Tal \|last4=Rega \|first4=Filip \|last5=Petrou \|first5=Mario \|last6=Rosendahl \|first6=Ulrich \|last7=Mohiaddin \|first7=Raad \|last8=Rubens \|first8=Michael \|last9=Thornton \|first9=Warren \|last10=Lees \|first10=Belinda \|last11=Pepper \|first11=John \|title=Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1–9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the published results of aortic root replacement \|journal=Heart \|date=15 June 2014 \|volume=100 \|issue=12 \|pages=969–975 \|id={{CORE output\|43293156}} {{ProQuest\|1780732212}} \|doi=10.1136/heartjnl-2013-304913 \|pmid=24395977 \|pmc=4033204 }}</ref>

	Since its inception, the PEARS procedure has been performed in several hospitals across England ~~and Belgium~~, demonstrating its potential as a viable treatment option. The procedure has undergone health technology appraisal by the [[National Institute for Health and Care Excellence]] (NICE), further validating its efficacy and safety.<ref name="NICE"/>		Since its inception, the PEARS procedure has been performed in several hospitals across England, demonstrating its potential as a viable treatment option. The procedure has undergone health technology appraisal by the [[National Institute for Health and Care Excellence]] (NICE), further validating its efficacy and safety.<ref name="NICE"/>

	==See also==		==See also==

wikipedia>Dclemens1971: Proposing article for deletion per WP:PROD.

2026-09-23T14:59:30Z

Proposing article for deletion per WP:PROD.

← Older revision		Revision as of 14:59, 23 September 2026
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	{{Short description\|Medical procedure for aortic root aneurysms}}		{{Short description\|Medical procedure for aortic root aneurysms}}
			{{Proposed deletion/dated
			\|concern = Proposing for deletion per [[WP:LLMPROD]]. Prose contains several [[WP:AISIGNS]]; several sources fail verification (for example, [https://www.nice.org.uk/guidance/htg623/resources/personalised-external-aortic-root-support-pears-using-mesh-to-prevent-aortic-root-expansion-and-aortic-dissection-in-people-with-marfan-syndrome-pdf-1809598463924677 fn 3] doesn't say anything about Belgium and it downplays the efficacy as "adequate" and unclear in the long run); and original version had a [https://doi.org/10.1053%2Fj.optechstcs.2021.03.001 non-existent DOI].
			\|timestamp = 20260923145930
			\|nom = Dclemens1971
			\|help = off
			}}
	{{Use dmy dates\|date=July 2025}}		{{Use dmy dates\|date=July 2025}}

← Older revision		Revision as of 07:31, 29 September 2026
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	{{Short description\|Medical procedure for aortic root aneurysms}}		{{Short description\|Medical procedure for aortic root aneurysms}}
	{{Use dmy dates\|date=July 2025}}		{{Use dmy dates\|date=July 2025}}
	~~<!-- Please do not remove or change this AfD message until the discussion has been closed. -->~~
	~~{{Article for deletion/dated\|page=Personalised external aortic root support\|timestamp=20260923162306\|year=2026\|month=September\|day=23\|substed=yes\|help=off}}~~
	~~<!-- Once discussion is closed, please place on talk page: {{Old AfD multi\|page=Personalised external aortic root support\|date=23 September 2026\|result='''keep'''}} -->~~
	~~<!-- End of AfD message, feel free to edit beyond this point -->~~
	The '''personalised external aortic root support''' ('''PEARS''') is a medical procedure for [[aortic root]] aneurysms, can be in patients with connective tissue disorders such as [[Marfan syndrome]]. This technique uses a bespoke microporous textile mesh jacket, tailored precisely to the dimensions of a persons aorta, providing an alternative to conventional surgical methods.<ref name="Kenny Austin Conal Personalized External">{{cite journal \|last1=Kenny \|first1=Louise A. \|last2=Austin \|first2=Conal \|last3=Golesworthy \|first3=Tal \|last4=Venugopal \|first4=Prem \|last5=Alphonso \|first5=Nelson \|title=Personalized External Aortic Root Support (PEARS) for Aortic Root Aneurysm \|journal=Operative Techniques in Thoracic and Cardiovascular Surgery \|date=Summer 2021 \|volume=26 \|issue=2 \|pages=290–305 \|doi=10.1053/j.optechstcvs.2021.03.001 \|doi-access=free }}</ref>		The '''personalised external aortic root support''' ('''PEARS''') is a medical procedure for [[aortic root]] aneurysms, can be in patients with connective tissue disorders such as [[Marfan syndrome]]. This technique uses a bespoke microporous textile mesh jacket, tailored precisely to the dimensions of a persons aorta, providing an alternative to conventional surgical methods.<ref name="Kenny Austin Conal Personalized External">{{cite journal \|last1=Kenny \|first1=Louise A. \|last2=Austin \|first2=Conal \|last3=Golesworthy \|first3=Tal \|last4=Venugopal \|first4=Prem \|last5=Alphonso \|first5=Nelson \|title=Personalized External Aortic Root Support (PEARS) for Aortic Root Aneurysm \|journal=Operative Techniques in Thoracic and Cardiovascular Surgery \|date=Summer 2021 \|volume=26 \|issue=2 \|pages=290–305 \|doi=10.1053/j.optechstcvs.2021.03.001 \|doi-access=free }}</ref>