CYC1 - Revision history

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	~~{{Short description\|Protein-coding gene in the species Homo sapiens}}~~
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	~~{{Article for deletion/dated\|page=CYC1\|timestamp=20261001073249\|year=2026\|month=October\|day=1\|substed=yes\|help=off\|outcome=merging\|target=Cytochrome C1}}~~
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2026-10-01T07:32:49Z

Nominated for merging; see Wikipedia:Articles for deletion/CYC1.

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			{{Article for deletion/dated\|page=CYC1\|timestamp=20261001073249\|year=2026\|month=October\|day=1\|substed=yes\|help=off\|outcome=merging\|target=Cytochrome C1}}
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2025-08-18T08:24:12Z

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← Older revision		Revision as of 08:24, 18 August 2025
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	* {{cite journal \| vauthors = Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T \| title = Structural organization of the human mitochondrial cytochrome c1 gene \| journal = The Journal of Biological Chemistry \| volume = 264 \| issue = 3 \| pages = 1368–74 \| date = January 1989 \| doi = 10.1016/S0021-9258(18)94196-7 \| pmid = 2536365 \| doi-access = free }}		* {{cite journal \| vauthors = Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T \| title = Structural organization of the human mitochondrial cytochrome c1 gene \| journal = The Journal of Biological Chemistry \| volume = 264 \| issue = 3 \| pages = 1368–74 \| date = January 1989 \| doi = 10.1016/S0021-9258(18)94196-7 \| pmid = 2536365 \| doi-access = free }}
	* {{cite journal \| vauthors = Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T \| title = Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 \| journal = Nucleic Acids Research \| volume = 16 \| issue = 8 \| pages = 3577 \| date = April 1988 \| pmid = 2836796 \| pmc = 336517 \| doi = 10.1093/nar/16.8.3577 }}		* {{cite journal \| vauthors = Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T \| title = Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 \| journal = Nucleic Acids Research \| volume = 16 \| issue = 8 \| pages = 3577 \| date = April 1988 \| pmid = 2836796 \| pmc = 336517 \| doi = 10.1093/nar/16.8.3577 }}
	* {{cite journal \| vauthors = Tanaka Y, Ashikari T, Shibano Y, Amachi T, Yoshizumi H, Matsubara H \| title = Construction of a human cytochrome c gene and its functional expression in Saccharomyces cerevisiae \| journal = Journal of Biochemistry \| volume = 103 \| issue = 6 \| pages = 954–61 \| date = June 1988 \| pmid = 2844747 \| doi = 10.1093/oxfordjournals.jbchem.a122393}}		* {{cite journal \| vauthors = Tanaka Y, Ashikari T, Shibano Y, Amachi T, Yoshizumi H, Matsubara H \| title = Construction of a human cytochrome c gene and its functional expression in Saccharomyces cerevisiae \| journal = Journal of Biochemistry \| volume = 103 \| issue = 6 \| pages = 954–61 \| date = June 1988 \| pmid = 2844747 \| doi = 10.1093/oxfordjournals.jbchem.a122393\| doi-access = free }}
	* {{cite journal \| vauthors = Shimomura Y, Nishikimi M, Ozawa T \| title = Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1 \| journal = The Journal of Biological Chemistry \| volume = 260 \| issue = 28 \| pages = 15075–80 \| date = December 1985 \| doi = 10.1016/S0021-9258(18)95704-2 \| pmid = 2999105 \| doi-access = free }}		* {{cite journal \| vauthors = Shimomura Y, Nishikimi M, Ozawa T \| title = Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1 \| journal = The Journal of Biological Chemistry \| volume = 260 \| issue = 28 \| pages = 15075–80 \| date = December 1985 \| doi = 10.1016/S0021-9258(18)95704-2 \| pmid = 2999105 \| doi-access = free }}
	* {{cite journal \| vauthors = Nishikimi M, Suzuki H, Ohta S, Sakurai T, Shimomura Y, Tanaka M, Kagawa Y, Ozawa T \| title = Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library \| journal = Biochemical and Biophysical Research Communications \| volume = 145 \| issue = 1 \| pages = 34–9 \| date = May 1987 \| pmid = 3036122 \| doi = 10.1016/0006-291X(87)91283-6 }}		* {{cite journal \| vauthors = Nishikimi M, Suzuki H, Ohta S, Sakurai T, Shimomura Y, Tanaka M, Kagawa Y, Ozawa T \| title = Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library \| journal = Biochemical and Biophysical Research Communications \| volume = 145 \| issue = 1 \| pages = 34–9 \| date = May 1987 \| pmid = 3036122 \| doi = 10.1016/0006-291X(87)91283-6 }}

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2025-07-19T05:32:11Z

Move 1 url. Wayback Medic 2.5 per WP:URLREQ#nih.gov

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	{{cs1 config\|name-list-style=vanc}}		{{cs1 config\|name-list-style=vanc}}
	{{Infobox_gene}}		{{Infobox_gene}}
	'''Cytochrome c1, heme protein, mitochondrial (CYC1),''' also known as '''UQCR4, MC3DN6, Complex III subunit 4, Cytochrome b-c1 complex subunit 4,''' or '''Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit''' is a [[protein]] that in humans is encoded by the ''CYC1'' [[gene]]. CYC1 is a respiratory [[Protein subunit\|subunit]] of [[ubiquinol-cytochrome-c reductase\|Ubiquinol Cytochrome c Reductase]] ([[Coenzyme Q – cytochrome c reductase\|complex III]]), which is located in the [[inner mitochondrial membrane]] and is part of the [[electron transport chain]]. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear, type 6.<ref name="entrez">{{cite web \| title = Entrez Gene: CYC1 cytochrome c-1\| url = https://www.ncbi.nlm.nih.gov/~~sites/entrez~~?Db=gene&Cmd=ShowDetailView&TermToSearch=1537}}</ref><ref name=":0">{{Cite web\|url=https://www.uniprot.org/uniprot/P08574\|title=CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Homo sapiens (Human) - CYC1 gene & protein\|website=www.uniprot.org\|language=en\|access-date=2018-07-31}}</ref><ref name=":3">{{cite journal \| title = UniProt: the universal protein knowledgebase \| journal = Nucleic Acids Research \| volume = 45 \| issue = D1 \| pages = D158–D169 \| date = January 2017 \| pmid = 27899622 \| pmc = 5210571 \| doi = 10.1093/nar/gkw1099 }}</ref>		'''Cytochrome c1, heme protein, mitochondrial (CYC1),''' also known as '''UQCR4, MC3DN6, Complex III subunit 4, Cytochrome b-c1 complex subunit 4,''' or '''Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit''' is a [[protein]] that in humans is encoded by the ''CYC1'' [[gene]]. CYC1 is a respiratory [[Protein subunit\|subunit]] of [[ubiquinol-cytochrome-c reductase\|Ubiquinol Cytochrome c Reductase]] ([[Coenzyme Q – cytochrome c reductase\|complex III]]), which is located in the [[inner mitochondrial membrane]] and is part of the [[electron transport chain]]. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear, type 6.<ref name="entrez">{{cite web \| title = Entrez Gene: CYC1 cytochrome c-1\| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1537}}</ref><ref name=":0">{{Cite web\|url=https://www.uniprot.org/uniprot/P08574\|title=CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Homo sapiens (Human) - CYC1 gene & protein\|website=www.uniprot.org\|language=en\|access-date=2018-07-31}}</ref><ref name=":3">{{cite journal \| title = UniProt: the universal protein knowledgebase \| journal = Nucleic Acids Research \| volume = 45 \| issue = D1 \| pages = D158–D169 \| date = January 2017 \| pmid = 27899622 \| pmc = 5210571 \| doi = 10.1093/nar/gkw1099 }}</ref>

	== Structure ==		== Structure ==

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2024-04-01T05:45:07Z

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	== Further reading ==		== Further reading ==
	{{refbegin \| 2}}		{{refbegin \| 2}}
	* {{cite journal \| vauthors = Moon HS, Yang JS \| title = Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells \| journal = Molecules and Cells \| volume = 21 \| issue = 1 \| pages = 7–20 \| date = February 2006 \| doi = 10.1016/s1016-8478(23)12897-4 \| pmid = 16511342 }}		* {{cite journal \| vauthors = Moon HS, Yang JS \| title = Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells \| journal = Molecules and Cells \| volume = 21 \| issue = 1 \| pages = 7–20 \| date = February 2006 \| doi = 10.1016/s1016-8478(23)12897-4 \| pmid = 16511342 \| doi-access = free }}
	* {{cite journal \| vauthors = Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T \| title = Structural organization of the human mitochondrial cytochrome c1 gene \| journal = The Journal of Biological Chemistry \| volume = 264 \| issue = 3 \| pages = 1368–74 \| date = January 1989 \| doi = 10.1016/S0021-9258(18)94196-7 \| pmid = 2536365 \| doi-access = free }}		* {{cite journal \| vauthors = Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T \| title = Structural organization of the human mitochondrial cytochrome c1 gene \| journal = The Journal of Biological Chemistry \| volume = 264 \| issue = 3 \| pages = 1368–74 \| date = January 1989 \| doi = 10.1016/S0021-9258(18)94196-7 \| pmid = 2536365 \| doi-access = free }}
	* {{cite journal \| vauthors = Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T \| title = Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 \| journal = Nucleic Acids Research \| volume = 16 \| issue = 8 \| pages = 3577 \| date = April 1988 \| pmid = 2836796 \| pmc = 336517 \| doi = 10.1093/nar/16.8.3577 }}		* {{cite journal \| vauthors = Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T \| title = Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 \| journal = Nucleic Acids Research \| volume = 16 \| issue = 8 \| pages = 3577 \| date = April 1988 \| pmid = 2836796 \| pmc = 336517 \| doi = 10.1093/nar/16.8.3577 }}

wikipedia>Maxim Masiutin: Added the cs1 style template to denote Vancouver ("vanc") citation style, because references contain "vauthors" attribute to specify the list of authors. Added doi. | Use this tool. Report bugs. | #UCB_Gadget

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Added the cs1 style template to denote Vancouver ("vanc") citation style, because references contain "vauthors" attribute to specify the list of authors. Added doi. | Use this tool. Report bugs. | #UCB_Gadget

← Older revision		Revision as of 22:25, 27 March 2024
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	{{Short description\|Protein-coding gene in the species Homo sapiens}}		{{Short description\|Protein-coding gene in the species Homo sapiens}}
			{{cs1 config\|name-list-style=vanc}}
	{{Infobox_gene}}		{{Infobox_gene}}
	'''Cytochrome c1, heme protein, mitochondrial (CYC1),''' also known as '''UQCR4, MC3DN6, Complex III subunit 4, Cytochrome b-c1 complex subunit 4,''' or '''Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit''' is a [[protein]] that in humans is encoded by the ''CYC1'' [[gene]]. CYC1 is a respiratory [[Protein subunit\|subunit]] of [[ubiquinol-cytochrome-c reductase\|Ubiquinol Cytochrome c Reductase]] ([[Coenzyme Q – cytochrome c reductase\|complex III]]), which is located in the [[inner mitochondrial membrane]] and is part of the [[electron transport chain]]. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear, type 6.<ref name="entrez">{{cite web \| title = Entrez Gene: CYC1 cytochrome c-1\| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1537}}</ref><ref name=":0">{{Cite web\|url=https://www.uniprot.org/uniprot/P08574\|title=CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Homo sapiens (Human) - CYC1 gene & protein\|website=www.uniprot.org\|language=en\|access-date=2018-07-31}}</ref><ref name=":3">{{cite journal \| title = UniProt: the universal protein knowledgebase \| journal = Nucleic Acids Research \| volume = 45 \| issue = D1 \| pages = D158–D169 \| date = January 2017 \| pmid = 27899622 \| pmc = 5210571 \| doi = 10.1093/nar/gkw1099 }}</ref>		'''Cytochrome c1, heme protein, mitochondrial (CYC1),''' also known as '''UQCR4, MC3DN6, Complex III subunit 4, Cytochrome b-c1 complex subunit 4,''' or '''Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit''' is a [[protein]] that in humans is encoded by the ''CYC1'' [[gene]]. CYC1 is a respiratory [[Protein subunit\|subunit]] of [[ubiquinol-cytochrome-c reductase\|Ubiquinol Cytochrome c Reductase]] ([[Coenzyme Q – cytochrome c reductase\|complex III]]), which is located in the [[inner mitochondrial membrane]] and is part of the [[electron transport chain]]. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear, type 6.<ref name="entrez">{{cite web \| title = Entrez Gene: CYC1 cytochrome c-1\| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1537}}</ref><ref name=":0">{{Cite web\|url=https://www.uniprot.org/uniprot/P08574\|title=CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Homo sapiens (Human) - CYC1 gene & protein\|website=www.uniprot.org\|language=en\|access-date=2018-07-31}}</ref><ref name=":3">{{cite journal \| title = UniProt: the universal protein knowledgebase \| journal = Nucleic Acids Research \| volume = 45 \| issue = D1 \| pages = D158–D169 \| date = January 2017 \| pmid = 27899622 \| pmc = 5210571 \| doi = 10.1093/nar/gkw1099 }}</ref>
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	== Further reading ==		== Further reading ==
	{{refbegin \| 2}}		{{refbegin \| 2}}
	* {{cite journal \| vauthors = Moon HS, Yang JS \| title = Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells \| journal = Molecules and Cells \| volume = 21 \| issue = 1 \| pages = 7–20 \| date = February 2006 \| pmid = 16511342 }}		* {{cite journal \| vauthors = Moon HS, Yang JS \| title = Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells \| journal = Molecules and Cells \| volume = 21 \| issue = 1 \| pages = 7–20 \| date = February 2006 \| doi = 10.1016/s1016-8478(23)12897-4 \| pmid = 16511342 }}
	* {{cite journal \| vauthors = Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T \| title = Structural organization of the human mitochondrial cytochrome c1 gene \| journal = The Journal of Biological Chemistry \| volume = 264 \| issue = 3 \| pages = 1368–74 \| date = January 1989 \| doi = 10.1016/S0021-9258(18)94196-7 \| pmid = 2536365 \| doi-access = free }}		* {{cite journal \| vauthors = Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T \| title = Structural organization of the human mitochondrial cytochrome c1 gene \| journal = The Journal of Biological Chemistry \| volume = 264 \| issue = 3 \| pages = 1368–74 \| date = January 1989 \| doi = 10.1016/S0021-9258(18)94196-7 \| pmid = 2536365 \| doi-access = free }}
	* {{cite journal \| vauthors = Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T \| title = Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 \| journal = Nucleic Acids Research \| volume = 16 \| issue = 8 \| pages = 3577 \| date = April 1988 \| pmid = 2836796 \| pmc = 336517 \| doi = 10.1093/nar/16.8.3577 }}		* {{cite journal \| vauthors = Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T \| title = Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 \| journal = Nucleic Acids Research \| volume = 16 \| issue = 8 \| pages = 3577 \| date = April 1988 \| pmid = 2836796 \| pmc = 336517 \| doi = 10.1093/nar/16.8.3577 }}

wikipedia>Ffffrr: Importing Wikidata short description: "Protein-coding gene in the species Homo sapiens" (Shortdesc helper)

2022-04-09T00:48:17Z

Importing Wikidata short description: "Protein-coding gene in the species Homo sapiens" (Shortdesc helper)

← Older revision		Revision as of 00:48, 9 April 2022
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			{{Short description\|Protein-coding gene in the species Homo sapiens}}
	{{Infobox_gene}}		{{Infobox_gene}}
	'''Cytochrome c1, heme protein, mitochondrial (CYC1),''' also known as '''UQCR4, MC3DN6, Complex III subunit 4, Cytochrome b-c1 complex subunit 4,''' or '''Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit''' is a [[protein]] that in humans is encoded by the ''CYC1'' [[gene]]. CYC1 is a respiratory [[Protein subunit\|subunit]] of [[ubiquinol-cytochrome-c reductase\|Ubiquinol Cytochrome c Reductase]] ([[Coenzyme Q – cytochrome c reductase\|complex III]]), which is located in the [[inner mitochondrial membrane]] and is part of the [[electron transport chain]]. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear, type 6.<ref name="entrez">{{cite web \| title = Entrez Gene: CYC1 cytochrome c-1\| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1537}}</ref><ref name=":0">{{Cite web\|url=https://www.uniprot.org/uniprot/P08574\|title=CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Homo sapiens (Human) - CYC1 gene & protein\|website=www.uniprot.org\|language=en\|access-date=2018-07-31}}</ref><ref name=":3">{{cite journal \| title = UniProt: the universal protein knowledgebase \| journal = Nucleic Acids Research \| volume = 45 \| issue = D1 \| pages = D158–D169 \| date = January 2017 \| pmid = 27899622 \| pmc = 5210571 \| doi = 10.1093/nar/gkw1099 }}</ref>		'''Cytochrome c1, heme protein, mitochondrial (CYC1),''' also known as '''UQCR4, MC3DN6, Complex III subunit 4, Cytochrome b-c1 complex subunit 4,''' or '''Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit''' is a [[protein]] that in humans is encoded by the ''CYC1'' [[gene]]. CYC1 is a respiratory [[Protein subunit\|subunit]] of [[ubiquinol-cytochrome-c reductase\|Ubiquinol Cytochrome c Reductase]] ([[Coenzyme Q – cytochrome c reductase\|complex III]]), which is located in the [[inner mitochondrial membrane]] and is part of the [[electron transport chain]]. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear, type 6.<ref name="entrez">{{cite web \| title = Entrez Gene: CYC1 cytochrome c-1\| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1537}}</ref><ref name=":0">{{Cite web\|url=https://www.uniprot.org/uniprot/P08574\|title=CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Homo sapiens (Human) - CYC1 gene & protein\|website=www.uniprot.org\|language=en\|access-date=2018-07-31}}</ref><ref name=":3">{{cite journal \| title = UniProt: the universal protein knowledgebase \| journal = Nucleic Acids Research \| volume = 45 \| issue = D1 \| pages = D158–D169 \| date = January 2017 \| pmid = 27899622 \| pmc = 5210571 \| doi = 10.1093/nar/gkw1099 }}</ref>

wikipedia>BrownHairedGirl: remove stray angle brackets inside ref tag, replaced: < →

2021-12-15T06:04:32Z

remove stray angle brackets inside ref tag, replaced: <</ref> → </ref>

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	== Interactions ==		== Interactions ==
	CYC1 has 78 protein-protein interactions with 72 of them being co-complex interactions.<ref name=":1">{{cite web \| url = https://www.ebi.ac.uk/intact/interactions?conversationContext=3&query=CYC1 \| title = 81 binary interactions found for search term CYC1 \| work = IntAct Molecular Interaction Database \| publisher = EMBL-EBI \| access-date = 2018-08-25 }}<</ref> CYC1 is one of 11 subunits of [[ubiquinol-cytochrome-c reductase\|Ubiquinol Cytochrome c Reductase]] (b1-c complex) that includes the respiratory subunits [[cytochrome b]], [[Cytochrome C1\|cytochrome c1]] (CYC1), [[UQCRFS1]], the core proteins [[UQCRC1]] and [[UQCRC2]], and the low-molecular weight proteins [[UQCRH]], [[UQCRB]], [[UQCRQ]], [[UQCR10 (gene)\|UQCR10]], [[UQCR11]], as well as an additional cleavage product of UQCRFS1.<ref name=":0" /><ref name=":3" /> Additionally, CCP1, CDKA-1, and CDKB1-1 have also been found to interact with CYC1.<ref name=":1" />		CYC1 has 78 protein-protein interactions with 72 of them being co-complex interactions.<ref name=":1">{{cite web \| url = https://www.ebi.ac.uk/intact/interactions?conversationContext=3&query=CYC1 \| title = 81 binary interactions found for search term CYC1 \| work = IntAct Molecular Interaction Database \| publisher = EMBL-EBI \| access-date = 2018-08-25 }}</ref> CYC1 is one of 11 subunits of [[ubiquinol-cytochrome-c reductase\|Ubiquinol Cytochrome c Reductase]] (b1-c complex) that includes the respiratory subunits [[cytochrome b]], [[Cytochrome C1\|cytochrome c1]] (CYC1), [[UQCRFS1]], the core proteins [[UQCRC1]] and [[UQCRC2]], and the low-molecular weight proteins [[UQCRH]], [[UQCRB]], [[UQCRQ]], [[UQCR10 (gene)\|UQCR10]], [[UQCR11]], as well as an additional cleavage product of UQCRFS1.<ref name=":0" /><ref name=":3" /> Additionally, CCP1, CDKA-1, and CDKB1-1 have also been found to interact with CYC1.<ref name=":1" />

	== References ==		== References ==

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2021-07-05T23:02:33Z

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	* {{cite journal \| vauthors = Brenner C, Kroemer G \| title = The mitochondriotoxic domain of Vpr determines HIV-1 virulence \| journal = The Journal of Clinical Investigation \| volume = 111 \| issue = 10 \| pages = 1455–7 \| date = May 2003 \| pmid = 12750393 \| pmc = 155055 \| doi = 10.1172/JCI18609 }}		* {{cite journal \| vauthors = Brenner C, Kroemer G \| title = The mitochondriotoxic domain of Vpr determines HIV-1 virulence \| journal = The Journal of Clinical Investigation \| volume = 111 \| issue = 10 \| pages = 1455–7 \| date = May 2003 \| pmid = 12750393 \| pmc = 155055 \| doi = 10.1172/JCI18609 }}
	* {{cite journal \| vauthors = Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao XJ, Lynch D, Pilon AA, Hawley N, Kim JE, Chen Z, Montpetit M, Sanchez-Dardon J, Cohen EA, Badley AD \| title = Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis \| journal = The Journal of Clinical Investigation \| volume = 111 \| issue = 10 \| pages = 1547–54 \| date = May 2003 \| pmid = 12750404 \| pmc = 155040 \| doi = 10.1172/JCI16233 }}		* {{cite journal \| vauthors = Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao XJ, Lynch D, Pilon AA, Hawley N, Kim JE, Chen Z, Montpetit M, Sanchez-Dardon J, Cohen EA, Badley AD \| title = Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis \| journal = The Journal of Clinical Investigation \| volume = 111 \| issue = 10 \| pages = 1547–54 \| date = May 2003 \| pmid = 12750404 \| pmc = 155040 \| doi = 10.1172/JCI16233 }}
	* {{cite journal \| vauthors = Yuan J, Murrell GA, Trickett A, Wang MX \| title = Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts \| journal = Biochimica et Biophysica Acta (BBA) - Molecular Cell Research \| volume = 1641 \| issue = 1 \| pages = 35–41 \| date = June 2003 \| pmid = 12788227 \| doi = 10.1016/S0167-4889(03)00047-8 }}		* {{cite journal \| vauthors = Yuan J, Murrell GA, Trickett A, Wang MX \| title = Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts \| journal = Biochimica et Biophysica Acta (BBA) - Molecular Cell Research \| volume = 1641 \| issue = 1 \| pages = 35–41 \| date = June 2003 \| pmid = 12788227 \| doi = 10.1016/S0167-4889(03)00047-8 \| doi-access = free }}
	* {{cite journal \| vauthors = An J, Chen Y, Huang Z \| title = Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor \| journal = The Journal of Biological Chemistry \| volume = 279 \| issue = 18 \| pages = 19133–40 \| date = April 2004 \| pmid = 14966123 \| doi = 10.1074/jbc.M400295200 \| doi-access = free }}		* {{cite journal \| vauthors = An J, Chen Y, Huang Z \| title = Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor \| journal = The Journal of Biological Chemistry \| volume = 279 \| issue = 18 \| pages = 19133–40 \| date = April 2004 \| pmid = 14966123 \| doi = 10.1074/jbc.M400295200 \| doi-access = free }}
	{{refend}}		{{refend}}

← Older revision		Revision as of 08:24, 18 August 2025
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	* {{cite journal \| vauthors = Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T \| title = Structural organization of the human mitochondrial cytochrome c1 gene \| journal = The Journal of Biological Chemistry \| volume = 264 \| issue = 3 \| pages = 1368–74 \| date = January 1989 \| doi = 10.1016/S0021-9258(18)94196-7 \| pmid = 2536365 \| doi-access = free }}		* {{cite journal \| vauthors = Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T \| title = Structural organization of the human mitochondrial cytochrome c1 gene \| journal = The Journal of Biological Chemistry \| volume = 264 \| issue = 3 \| pages = 1368–74 \| date = January 1989 \| doi = 10.1016/S0021-9258(18)94196-7 \| pmid = 2536365 \| doi-access = free }}
	* {{cite journal \| vauthors = Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T \| title = Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 \| journal = Nucleic Acids Research \| volume = 16 \| issue = 8 \| pages = 3577 \| date = April 1988 \| pmid = 2836796 \| pmc = 336517 \| doi = 10.1093/nar/16.8.3577 }}		* {{cite journal \| vauthors = Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T \| title = Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 \| journal = Nucleic Acids Research \| volume = 16 \| issue = 8 \| pages = 3577 \| date = April 1988 \| pmid = 2836796 \| pmc = 336517 \| doi = 10.1093/nar/16.8.3577 }}
	* {{cite journal \| vauthors = Tanaka Y, Ashikari T, Shibano Y, Amachi T, Yoshizumi H, Matsubara H \| title = Construction of a human cytochrome c gene and its functional expression in Saccharomyces cerevisiae \| journal = Journal of Biochemistry \| volume = 103 \| issue = 6 \| pages = 954–61 \| date = June 1988 \| pmid = 2844747 \| doi = 10.1093/oxfordjournals.jbchem.a122393}}		* {{cite journal \| vauthors = Tanaka Y, Ashikari T, Shibano Y, Amachi T, Yoshizumi H, Matsubara H \| title = Construction of a human cytochrome c gene and its functional expression in Saccharomyces cerevisiae \| journal = Journal of Biochemistry \| volume = 103 \| issue = 6 \| pages = 954–61 \| date = June 1988 \| pmid = 2844747 \| doi = 10.1093/oxfordjournals.jbchem.a122393\| doi-access = free }}
	* {{cite journal \| vauthors = Shimomura Y, Nishikimi M, Ozawa T \| title = Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1 \| journal = The Journal of Biological Chemistry \| volume = 260 \| issue = 28 \| pages = 15075–80 \| date = December 1985 \| doi = 10.1016/S0021-9258(18)95704-2 \| pmid = 2999105 \| doi-access = free }}		* {{cite journal \| vauthors = Shimomura Y, Nishikimi M, Ozawa T \| title = Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1 \| journal = The Journal of Biological Chemistry \| volume = 260 \| issue = 28 \| pages = 15075–80 \| date = December 1985 \| doi = 10.1016/S0021-9258(18)95704-2 \| pmid = 2999105 \| doi-access = free }}
	* {{cite journal \| vauthors = Nishikimi M, Suzuki H, Ohta S, Sakurai T, Shimomura Y, Tanaka M, Kagawa Y, Ozawa T \| title = Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library \| journal = Biochemical and Biophysical Research Communications \| volume = 145 \| issue = 1 \| pages = 34–9 \| date = May 1987 \| pmid = 3036122 \| doi = 10.1016/0006-291X(87)91283-6 }}		* {{cite journal \| vauthors = Nishikimi M, Suzuki H, Ohta S, Sakurai T, Shimomura Y, Tanaka M, Kagawa Y, Ozawa T \| title = Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library \| journal = Biochemical and Biophysical Research Communications \| volume = 145 \| issue = 1 \| pages = 34–9 \| date = May 1987 \| pmid = 3036122 \| doi = 10.1016/0006-291X(87)91283-6 }}

← Older revision		Revision as of 05:45, 1 April 2024
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	== Further reading ==		== Further reading ==
	{{refbegin \| 2}}		{{refbegin \| 2}}
	* {{cite journal \| vauthors = Moon HS, Yang JS \| title = Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells \| journal = Molecules and Cells \| volume = 21 \| issue = 1 \| pages = 7–20 \| date = February 2006 \| doi = 10.1016/s1016-8478(23)12897-4 \| pmid = 16511342 }}		* {{cite journal \| vauthors = Moon HS, Yang JS \| title = Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells \| journal = Molecules and Cells \| volume = 21 \| issue = 1 \| pages = 7–20 \| date = February 2006 \| doi = 10.1016/s1016-8478(23)12897-4 \| pmid = 16511342 \| doi-access = free }}
	* {{cite journal \| vauthors = Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T \| title = Structural organization of the human mitochondrial cytochrome c1 gene \| journal = The Journal of Biological Chemistry \| volume = 264 \| issue = 3 \| pages = 1368–74 \| date = January 1989 \| doi = 10.1016/S0021-9258(18)94196-7 \| pmid = 2536365 \| doi-access = free }}		* {{cite journal \| vauthors = Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T \| title = Structural organization of the human mitochondrial cytochrome c1 gene \| journal = The Journal of Biological Chemistry \| volume = 264 \| issue = 3 \| pages = 1368–74 \| date = January 1989 \| doi = 10.1016/S0021-9258(18)94196-7 \| pmid = 2536365 \| doi-access = free }}
	* {{cite journal \| vauthors = Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T \| title = Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 \| journal = Nucleic Acids Research \| volume = 16 \| issue = 8 \| pages = 3577 \| date = April 1988 \| pmid = 2836796 \| pmc = 336517 \| doi = 10.1093/nar/16.8.3577 }}		* {{cite journal \| vauthors = Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T \| title = Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 \| journal = Nucleic Acids Research \| volume = 16 \| issue = 8 \| pages = 3577 \| date = April 1988 \| pmid = 2836796 \| pmc = 336517 \| doi = 10.1093/nar/16.8.3577 }}

← Older revision		Revision as of 22:25, 27 March 2024
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	{{Short description\|Protein-coding gene in the species Homo sapiens}}		{{Short description\|Protein-coding gene in the species Homo sapiens}}
			{{cs1 config\|name-list-style=vanc}}
	{{Infobox_gene}}		{{Infobox_gene}}
	'''Cytochrome c1, heme protein, mitochondrial (CYC1),''' also known as '''UQCR4, MC3DN6, Complex III subunit 4, Cytochrome b-c1 complex subunit 4,''' or '''Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit''' is a [[protein]] that in humans is encoded by the ''CYC1'' [[gene]]. CYC1 is a respiratory [[Protein subunit\|subunit]] of [[ubiquinol-cytochrome-c reductase\|Ubiquinol Cytochrome c Reductase]] ([[Coenzyme Q – cytochrome c reductase\|complex III]]), which is located in the [[inner mitochondrial membrane]] and is part of the [[electron transport chain]]. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear, type 6.<ref name="entrez">{{cite web \| title = Entrez Gene: CYC1 cytochrome c-1\| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1537}}</ref><ref name=":0">{{Cite web\|url=https://www.uniprot.org/uniprot/P08574\|title=CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Homo sapiens (Human) - CYC1 gene & protein\|website=www.uniprot.org\|language=en\|access-date=2018-07-31}}</ref><ref name=":3">{{cite journal \| title = UniProt: the universal protein knowledgebase \| journal = Nucleic Acids Research \| volume = 45 \| issue = D1 \| pages = D158–D169 \| date = January 2017 \| pmid = 27899622 \| pmc = 5210571 \| doi = 10.1093/nar/gkw1099 }}</ref>		'''Cytochrome c1, heme protein, mitochondrial (CYC1),''' also known as '''UQCR4, MC3DN6, Complex III subunit 4, Cytochrome b-c1 complex subunit 4,''' or '''Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit''' is a [[protein]] that in humans is encoded by the ''CYC1'' [[gene]]. CYC1 is a respiratory [[Protein subunit\|subunit]] of [[ubiquinol-cytochrome-c reductase\|Ubiquinol Cytochrome c Reductase]] ([[Coenzyme Q – cytochrome c reductase\|complex III]]), which is located in the [[inner mitochondrial membrane]] and is part of the [[electron transport chain]]. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear, type 6.<ref name="entrez">{{cite web \| title = Entrez Gene: CYC1 cytochrome c-1\| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1537}}</ref><ref name=":0">{{Cite web\|url=https://www.uniprot.org/uniprot/P08574\|title=CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Homo sapiens (Human) - CYC1 gene & protein\|website=www.uniprot.org\|language=en\|access-date=2018-07-31}}</ref><ref name=":3">{{cite journal \| title = UniProt: the universal protein knowledgebase \| journal = Nucleic Acids Research \| volume = 45 \| issue = D1 \| pages = D158–D169 \| date = January 2017 \| pmid = 27899622 \| pmc = 5210571 \| doi = 10.1093/nar/gkw1099 }}</ref>
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	== Further reading ==		== Further reading ==
	{{refbegin \| 2}}		{{refbegin \| 2}}
	* {{cite journal \| vauthors = Moon HS, Yang JS \| title = Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells \| journal = Molecules and Cells \| volume = 21 \| issue = 1 \| pages = 7–20 \| date = February 2006 \| pmid = 16511342 }}		* {{cite journal \| vauthors = Moon HS, Yang JS \| title = Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells \| journal = Molecules and Cells \| volume = 21 \| issue = 1 \| pages = 7–20 \| date = February 2006 \| doi = 10.1016/s1016-8478(23)12897-4 \| pmid = 16511342 }}
	* {{cite journal \| vauthors = Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T \| title = Structural organization of the human mitochondrial cytochrome c1 gene \| journal = The Journal of Biological Chemistry \| volume = 264 \| issue = 3 \| pages = 1368–74 \| date = January 1989 \| doi = 10.1016/S0021-9258(18)94196-7 \| pmid = 2536365 \| doi-access = free }}		* {{cite journal \| vauthors = Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T \| title = Structural organization of the human mitochondrial cytochrome c1 gene \| journal = The Journal of Biological Chemistry \| volume = 264 \| issue = 3 \| pages = 1368–74 \| date = January 1989 \| doi = 10.1016/S0021-9258(18)94196-7 \| pmid = 2536365 \| doi-access = free }}
	* {{cite journal \| vauthors = Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T \| title = Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 \| journal = Nucleic Acids Research \| volume = 16 \| issue = 8 \| pages = 3577 \| date = April 1988 \| pmid = 2836796 \| pmc = 336517 \| doi = 10.1093/nar/16.8.3577 }}		* {{cite journal \| vauthors = Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T \| title = Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1 \| journal = Nucleic Acids Research \| volume = 16 \| issue = 8 \| pages = 3577 \| date = April 1988 \| pmid = 2836796 \| pmc = 336517 \| doi = 10.1093/nar/16.8.3577 }}

← Older revision		Revision as of 23:02, 5 July 2021
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	* {{cite journal \| vauthors = Brenner C, Kroemer G \| title = The mitochondriotoxic domain of Vpr determines HIV-1 virulence \| journal = The Journal of Clinical Investigation \| volume = 111 \| issue = 10 \| pages = 1455–7 \| date = May 2003 \| pmid = 12750393 \| pmc = 155055 \| doi = 10.1172/JCI18609 }}		* {{cite journal \| vauthors = Brenner C, Kroemer G \| title = The mitochondriotoxic domain of Vpr determines HIV-1 virulence \| journal = The Journal of Clinical Investigation \| volume = 111 \| issue = 10 \| pages = 1455–7 \| date = May 2003 \| pmid = 12750393 \| pmc = 155055 \| doi = 10.1172/JCI18609 }}
	* {{cite journal \| vauthors = Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao XJ, Lynch D, Pilon AA, Hawley N, Kim JE, Chen Z, Montpetit M, Sanchez-Dardon J, Cohen EA, Badley AD \| title = Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis \| journal = The Journal of Clinical Investigation \| volume = 111 \| issue = 10 \| pages = 1547–54 \| date = May 2003 \| pmid = 12750404 \| pmc = 155040 \| doi = 10.1172/JCI16233 }}		* {{cite journal \| vauthors = Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao XJ, Lynch D, Pilon AA, Hawley N, Kim JE, Chen Z, Montpetit M, Sanchez-Dardon J, Cohen EA, Badley AD \| title = Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis \| journal = The Journal of Clinical Investigation \| volume = 111 \| issue = 10 \| pages = 1547–54 \| date = May 2003 \| pmid = 12750404 \| pmc = 155040 \| doi = 10.1172/JCI16233 }}
	* {{cite journal \| vauthors = Yuan J, Murrell GA, Trickett A, Wang MX \| title = Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts \| journal = Biochimica et Biophysica Acta (BBA) - Molecular Cell Research \| volume = 1641 \| issue = 1 \| pages = 35–41 \| date = June 2003 \| pmid = 12788227 \| doi = 10.1016/S0167-4889(03)00047-8 }}		* {{cite journal \| vauthors = Yuan J, Murrell GA, Trickett A, Wang MX \| title = Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts \| journal = Biochimica et Biophysica Acta (BBA) - Molecular Cell Research \| volume = 1641 \| issue = 1 \| pages = 35–41 \| date = June 2003 \| pmid = 12788227 \| doi = 10.1016/S0167-4889(03)00047-8 \| doi-access = free }}
	* {{cite journal \| vauthors = An J, Chen Y, Huang Z \| title = Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor \| journal = The Journal of Biological Chemistry \| volume = 279 \| issue = 18 \| pages = 19133–40 \| date = April 2004 \| pmid = 14966123 \| doi = 10.1074/jbc.M400295200 \| doi-access = free }}		* {{cite journal \| vauthors = An J, Chen Y, Huang Z \| title = Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor \| journal = The Journal of Biological Chemistry \| volume = 279 \| issue = 18 \| pages = 19133–40 \| date = April 2004 \| pmid = 14966123 \| doi = 10.1074/jbc.M400295200 \| doi-access = free }}
	{{refend}}		{{refend}}