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'''Krüppel''' is a [[gap gene]] which encodes a [[zinc finger]] protein with four tandemly repeated zinc finger domains.<ref>{{OMIM|165220}}</ref>
'''Krüppel''' is a gap gene which encodes a zinc finger protein with four tandemly repeated zinc finger domains.


Krüppel means, literally, "cripple" in German.
Krüppel means, literally, "cripple" in German.


Put into English, it actually controls the development of a zygote early on in its growth, causing a gap in the otherwise [[heterogeneous]] arrangement of cells. It also controls access to several other subsequent genes, imposing order on the developing embryo.<ref>http://www.flybase.org/allied-data/lk/interactive-fly/segment/kruppel1.htm</ref>
Put into English, it controls the development of a zygote early on in its growth, causing a gap in the otherwise heterogeneous arrangement of cells. It also controls access to several other subsequent genes, imposing order on the developing embryo.


See also [[Kruppel-like factors]] which have been recently investigated in the heart but are well characterised for their role in carcinogenesis.
See also Kruppel-like factors which have been recently investigated in the heart but are well characterised for their role in carcinogenesis.


==External links==
==External links==
* [http://www.bio.davidson.edu/courses/MolBio/fly/embryred.jpeg Diagram] at [[Davidson College]] - a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Kruppel (green) Hairy (red) and Giant (in blue)
* [http://www.bio.davidson.edu/courses/MolBio/fly/embryred.jpeg Diagram] at [[Davidson College]] - a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Krüppel (in blue) Hairy (green) and Giant (red).


==References==
<references/>
==External links==
* {{MeshName|Kruppel+protein,+Drosophila}}
* {{MeshName|Kruppel+protein,+Drosophila}}


[[Category:Genetics]]
[[Category:Genetics]]
 
{{ntnes}}
 
{{genetics-stub}}

Latest revision as of 18:06, 11 April 2009

Krüppel is a gap gene which encodes a zinc finger protein with four tandemly repeated zinc finger domains.

Krüppel means, literally, "cripple" in German.

Put into English, it controls the development of a zygote early on in its growth, causing a gap in the otherwise heterogeneous arrangement of cells. It also controls access to several other subsequent genes, imposing order on the developing embryo.

See also Kruppel-like factors which have been recently investigated in the heart but are well characterised for their role in carcinogenesis.

  • Diagram at Davidson College - a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Krüppel (in blue) Hairy (green) and Giant (red).