Archive:Lactocyte: Difference between revisions

m Putting back in a lost reference
→Milk secretion and regulation: Replacing controversial claim and primary research paper with context and book reference
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Lactocytes secrete milk continuously, but slowly.<ref name=":2" /> As the lactocytes produce milk globules within the alveoli, intra-alveolar pressure stretches the lactocytes which prevents the cells from producing and "pinching off" fatty globule membranes, causing a reduced fat content. As the milk is removed, pressure reduces, and the fat content of the milk increases.<ref>{{Cite web |title=NDC {{!}} Limitations of the bioactive factors Feedback Inhibitor of Lactation model |url=https://ndcinstitute.au/article/781aa171-6c68-49b5-ab73-ae372fa0769b/limitations-of-the-bioactive-factors-feedback-inhibitor-of-lactation-model |access-date=2026-09-11 |website=ndcinstitute.au}}</ref>
Lactocytes secrete milk continuously, but slowly.<ref name=":2" /> As the lactocytes produce milk globules within the alveoli, intra-alveolar pressure stretches the lactocytes which prevents the cells from producing and "pinching off" fatty globule membranes, causing a reduced fat content. As the milk is removed, pressure reduces, and the fat content of the milk increases.<ref>{{Cite web |title=NDC {{!}} Limitations of the bioactive factors Feedback Inhibitor of Lactation model |url=https://ndcinstitute.au/article/781aa171-6c68-49b5-ab73-ae372fa0769b/limitations-of-the-bioactive-factors-feedback-inhibitor-of-lactation-model |access-date=2026-09-11 |website=ndcinstitute.au}}</ref>


The feedback inhibitor of lactation (FIL) protein acts by reversible blockade to limit secretion by lactocytes. The protein and its effect on lactocytes are part of the feedback process whereby breast milk supply adapts to changing demand by the breastfeeding infant.<ref>{{Cite journal |last1=Peaker |first1=M. |last2=Wilde |first2=C. J. |date=July 1996 |title=Feedback control of milk secretion from milk |journal=Journal of Mammary Gland Biology and Neoplasia |volume=1 |issue=3 |pages=307–315 |doi=10.1007/BF02018083 |issn=1083-3021 |pmid=10887504}}</ref>
The mechanisms that control the amount of milk produced to try to match demand remain poorly understood. Some have hypothesized the existence of a protein (or multiple proteins), they term "feedback inhibitor of lactation", which accumulates and stops milk production, however the existence and identity of this protein have yet to be definitively proven. More recently, some have suggested that [[serotonin]] may play a part.<ref>{{cite book|vauthors=Anderson SM, MacLean PS, McManaman JL, Neville MC|chapter=Lactation and its hormonal control|title=Knobil and Neill’s Physiology of reproduction|year=2015|edition=4|pages=2055-105|ISBN=9780123977694}}</ref>


== References ==
== References ==