Krüppel: Difference between revisions
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'''Krüppel''' is a [[gap gene]] which encodes a [[zinc finger]] protein with four tandemly repeated zinc finger domains. | '''Krüppel''' is a [[gap gene]] which encodes a [[zinc finger]] protein with four tandemly repeated zinc finger domains.<ref>{{OMIM|165220}}</ref> | ||
Krüppel means, literally, "cripple" in German. | Krüppel means, literally, "cripple" in German. | ||
Put into English, it actually controls the development of a zygote early on in its growth, causing a gap in the otherwise [[heterogeneous]] arrangement of cells. It also controls access to several other subsequent genes, imposing order on the developing embryo | Put into English, it actually controls the development of a zygote early on in its growth, causing a gap in the otherwise [[heterogeneous]] arrangement of cells. It also controls access to several other subsequent genes, imposing order on the developing embryo.<ref>http://www.flybase.org/allied-data/lk/interactive-fly/segment/kruppel1.htm</ref> | ||
See also [[Kruppel-like factors]] which have been recently investigated in the heart but are well characterised for their role in carcinogenesis. | |||
==External links== | |||
* [http://www.bio.davidson.edu/courses/MolBio/fly/embryred.jpeg Diagram] at [[Davidson College]] - a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Kruppel (green) Hairy (red) and Giant (in blue) | |||
==References== | |||
<references/> | |||
==External links== | |||
* {{MeshName|Kruppel+protein,+Drosophila}} | |||
[[Category:Genetics]] | [[Category:Genetics]] | ||
{{genetics-stub}} | {{genetics-stub}} | ||
Revision as of 13:34, 16 April 2007
Krüppel is a gap gene which encodes a zinc finger protein with four tandemly repeated zinc finger domains.[1]
Krüppel means, literally, "cripple" in German.
Put into English, it actually controls the development of a zygote early on in its growth, causing a gap in the otherwise heterogeneous arrangement of cells. It also controls access to several other subsequent genes, imposing order on the developing embryo.[2]
See also Kruppel-like factors which have been recently investigated in the heart but are well characterised for their role in carcinogenesis.
External links
- Diagram at Davidson College - a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Kruppel (green) Hairy (red) and Giant (in blue)
References
External links
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