Krüppel: Difference between revisions
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'''Krüppel''' is a [[gap gene]] which encodes a [[zinc finger]] protein with four tandemly repeated zinc finger domains.[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=OMIM&dopt=Detailed&tmpl=dispomimTemplate&list_uids=165220] | '''Krüppel''' is a [[gap gene]] which encodes a [[zinc finger]] protein with four tandemly repeated zinc finger domains.[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=OMIM&dopt=Detailed&tmpl=dispomimTemplate&list_uids=165220] | ||
Krüppel means, literally, "cripple" in German. | |||
Put into English, it actually controls the development of a zygote early on in its growth, causing a gap in the otherwise [[heterogenous]] arrangement of cells. It also controls access to several other subsequent genes, imposing order on the developing embryo[http://www.flybase.org/allied-data/lk/interactive-fly/segment/kruppel1.htm]. | Put into English, it actually controls the development of a zygote early on in its growth, causing a gap in the otherwise [[heterogenous]] arrangement of cells. It also controls access to several other subsequent genes, imposing order on the developing embryo[http://www.flybase.org/allied-data/lk/interactive-fly/segment/kruppel1.htm] (See Fig. 1 : a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Kruppel (green) Hairy (red) and Giant (in blue)). | ||
Fig.1 [[Image:http://www.bio.davidson.edu/courses/MolBio/fly/embryred.jpeg]] | |||
See also [[Kruppel-like factors]] | See also [[Kruppel-like factors]] which have been recently investigated in the heart but are well characterised for their role in carcinogenesis. | ||
{{genetics-stub}} | {{genetics-stub}} | ||
{{science-stub}} | {{science-stub}} | ||
Revision as of 09:00, 29 August 2006
Krüppel is a gap gene which encodes a zinc finger protein with four tandemly repeated zinc finger domains.[1]
Krüppel means, literally, "cripple" in German.
Put into English, it actually controls the development of a zygote early on in its growth, causing a gap in the otherwise heterogenous arrangement of cells. It also controls access to several other subsequent genes, imposing order on the developing embryo[2] (See Fig. 1 : a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Kruppel (green) Hairy (red) and Giant (in blue)).
Fig.1 File:Http://www.bio.davidson.edu/courses/MolBio/fly/embryred.jpeg
See also Kruppel-like factors which have been recently investigated in the heart but are well characterised for their role in carcinogenesis.
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