View source for Insulin-like growth factor II IRES

{{Rfam_box|acc=RF00483|description=Insulin-like growth factor II IRES|abbreviation=IRES_IGF2|type=Cis-reg; IRES;|avg_length=118.4|avg_identity=95|ss=Published; {{PMID|11903044}}|se=Moxon SJ|type=Cis-reg; IRES;}}

The '''insulin-like growth factor II (IGF-II) internal ribosome entry site''' [[IRES]] is found in the [[5' UTR]] of IGF-II leader 2 [[mRNA]]. This [[cis-regulatory element|RNA element]] allows cap-independent [[translation]] of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.<ref>{{cite journal | last = Pedersen | first = SK | coauthors = Christiansen J, Hansen TO, Larsen MR, Nielsen FC | year = 2002 | title = Human insulin-like growth factor II leader 2 mediates internal initiation of translation | journal = Biochem J | volume = 363 | pages = 37&ndash;44 | pmid = 11903044 | doi = 10.1042/0264-6021:3630037}}</ref>

==References==

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== External links ==

* {{Rfam|id=RF00483|name=Insulin-like growth factor II IRES}}

[[Category:Cis-regulatory RNA elements]]

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