Insulin-like growth factor II IRES

Insulin-like growth factor II IRES

Type:	Cis-reg; IRES;
2° structure:	Published; PubMed
Seed alignment:	Moxon SJ
Avg length:	118.4 nucleotides
Avg identity:	95%

The insulin-like growth factor II (IGF-II) internal ribosome entry site IRES is found in the 5' UTR of IGF-II leader 2 mRNA. This RNA element allows cap-independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.^[1]

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References

↑ Pedersen, SK; Christiansen J, Hansen TO, Larsen MR, Nielsen FC (2002). "Human insulin-like growth factor II leader 2 mediates internal initiation of translation". Biochem J 363: 37–44. doi:10.1042/0264-6021:3630037. PMID 11903044.

External links

Rfam page for Insulin-like growth factor II IRES

[1] Pedersen, SK; Christiansen J, Hansen TO, Larsen MR, Nielsen FC (2002). "Human insulin-like growth factor II leader 2 mediates internal initiation of translation". Biochem J 363: 37–44. doi:10.1042/0264-6021:3630037. PMID 11903044.

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