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{{Rfam_box|acc=RF00483|description=Insulin-like growth factor II IRES|abbreviation=IRES_IGF2|type=Cis-reg; IRES;|avg_length=118.4|avg_identity=95|ss=Published; {{PMID|11903044}}|se=Moxon SJ|type=Cis-reg; IRES;}}
{{Rfam_box|acc=RF00483|description=Insulin-like growth factor II IRES|abbreviation=IRES_IGF2|type=Cis-reg; IRES;|avg_length=118.4|avg_identity=95|ss=Published; {{PMID|11903044}}|se=Moxon SJ|type=Cis-reg; IRES;}}


The '''insulin-like growth factor II (IGF-II) internal ribosome entry site''' [[IRES]] is found in the [[5' UTR]] of IGF-II leader 2 [[mRNA]]. This [[cis-regulatory element|RNA element]] allows cap-independent [[translation]] of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.<ref>{{cite journal | last = Pedersen | first = SK | coauthors = Christiansen J, Hansen TO, Larsen MR, Nielsen FC | year = 2002 | title = Human insulin-like growth factor II leader 2 mediates internal initiation of translation | journal = Biochem J | volume = 363 | pages = 37&ndash;44 | id = PMID 11903044}}</ref>
The '''insulin-like growth factor II (IGF-II) internal ribosome entry site''' [[IRES]] is found in the [[5' UTR]] of IGF-II leader 2 [[mRNA]]. This [[cis-regulatory element|RNA element]] allows cap-independent [[translation]] of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.<ref>{{cite journal | last = Pedersen | first = SK | coauthors = Christiansen J, Hansen TO, Larsen MR, Nielsen FC | year = 2002 | title = Human insulin-like growth factor II leader 2 mediates internal initiation of translation | journal = Biochem J | volume = 363 | pages = 37&ndash;44 | pmid = 11903044 | doi = 10.1042/0264-6021:3630037}}</ref>
 
Learning about growth factors can be quite useful for some.


==References==
==References==
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{{reflist|1}}
{{reflist|1}}


==External links==
== External links ==
 
* [http://rfam.sanger.ac.uk/family?entry=RF00483 Rfam page for Insulin-like growth factor II IRES]
* {{Rfam|id=RF00483|name=Insulin-like growth factor II IRES}}


[[Category:Cis-regulatory RNA elements]]
[[Category:Cis-regulatory RNA elements]]
{{molecular-cell-biology-stub}}

Latest revision as of 05:49, 17 June 2014

Insulin-like growth factor II IRES
Template:Abbreviation
Type: Cis-reg; IRES;
2° structure: Published; PubMed
Seed alignment: Moxon SJ
Avg length: 118.4 nucleotides
Avg identity: 95%

The insulin-like growth factor II (IGF-II) internal ribosome entry site IRES is found in the 5' UTR of IGF-II leader 2 mRNA. This RNA element allows cap-independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.[1]

Learning about growth factors can be quite useful for some.

References

  1. ↑ Pedersen, SK; Christiansen J, Hansen TO, Larsen MR, Nielsen FC (2002). "Human insulin-like growth factor II leader 2 mediates internal initiation of translation". Biochem J 363: 37–44. doi:10.1042/0264-6021:3630037. PMID 11903044. 
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