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{{Rfam_box|acc=RF00483|description=Insulin-like growth factor II IRES|abbreviation=IRES_IGF2|type=Cis-reg; IRES;|avg_length=118.4|avg_identity=95|ss=Published; {{PMID|11903044}}|se=Moxon SJ|type=Cis-reg; IRES;}}
{{Rfam_box|acc=RF00483|description=Insulin-like growth factor II IRES|abbreviation=IRES_IGF2|type=Cis-reg; IRES;|avg_length=118.4|avg_identity=95|ss=Published; {{PMID|11903044}}|se=Moxon SJ|type=Cis-reg; IRES;}}


This family represents the insulin-like growth factor II (IGF-II) internal ribosome entry site (IRES) which is found in the 5' UTR of IGF-II leader 2 mRNA. This family allows cap-independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development [1].  
The '''insulin-like growth factor II (IGF-II) internal ribosome entry site''' [[IRES]] is found in the [[5' UTR]] of IGF-II leader 2 [[mRNA]]. This [[cis-regulatory element|RNA element]] allows cap-independent [[translation]] of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.<ref>{{cite journal | last = Pedersen | first = SK | coauthors = Christiansen J, Hansen TO, Larsen MR, Nielsen FC | year = 2002 | title = Human insulin-like growth factor II leader 2 mediates internal initiation of translation | journal = Biochem J | volume = 363 | pages = 37&ndash;44 | id = PMID 11903044}}</ref>


==Reference==
==Reference==


{{reflist|1}}
{{reflist|1}}
* [1] {{cite journal | last = Pedersen | first = SK | coauthors = Christiansen J, Hansen TO, Larsen MR, Nielsen FC | year = 2002 | title = Human insulin-like growth factor II leader 2 mediates internal initiation of translation | journal = Biochem J | volume = 363 | pages = 37&ndash;44 | id = PMID 11903044}}


==External link==
==External link==

Revision as of 10:55, 11 July 2007

Insulin-like growth factor II IRES
Template:Abbreviation
Type: Cis-reg; IRES;
2° structure: Published; PubMed
Seed alignment: Moxon SJ
Avg length: 118.4 nucleotides
Avg identity: 95%

The insulin-like growth factor II (IGF-II) internal ribosome entry site IRES is found in the 5' UTR of IGF-II leader 2 mRNA. This RNA element allows cap-independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.[1]

Reference

  1. ↑ Pedersen, SK; Christiansen J, Hansen TO, Larsen MR, Nielsen FC (2002). "Human insulin-like growth factor II leader 2 mediates internal initiation of translation". Biochem J 363: 37–44. PMID 11903044. 
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