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== External links ==
== External links ==


* {{Rfam|id=RF00483|name=Insulin-like growth factor II IRES}}
*  
* [http://rfam.sanger.ac.uk/family?entry=RF00483 Rfam page for Insulin-like growth factor II IRES]


[[Category:Cis-regulatory RNA elements]]
[[Category:Cis-regulatory RNA elements]]
{{molecular-cell-biology-stub}}

Revision as of 23:02, 23 March 2009

Insulin-like growth factor II IRES
Template:Abbreviation
Type: Cis-reg; IRES;
2° structure: Published; PubMed
Seed alignment: Moxon SJ
Avg length: 118.4 nucleotides
Avg identity: 95%

The insulin-like growth factor II (IGF-II) internal ribosome entry site IRES is found in the 5' UTR of IGF-II leader 2 mRNA. This RNA element allows cap-independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.[1]

References

  1. ↑ Pedersen, SK; Christiansen J, Hansen TO, Larsen MR, Nielsen FC (2002). "Human insulin-like growth factor II leader 2 mediates internal initiation of translation". Biochem J 363: 37–44. doi:10.1042/0264-6021:3630037. PMID 11903044. 
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