Insulin-like growth factor II IRES: Difference between revisions
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The '''insulin-like growth factor II (IGF-II) internal ribosome entry site''' [[IRES]] is found in the [[5' UTR]] of IGF-II leader 2 [[mRNA]]. This [[cis-regulatory element|RNA element]] allows cap-independent [[translation]] of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.<ref>{{cite journal | last = Pedersen | first = SK | coauthors = Christiansen J, Hansen TO, Larsen MR, Nielsen FC | year = 2002 | title = Human insulin-like growth factor II leader 2 mediates internal initiation of translation | journal = Biochem J | volume = 363 | pages = 37–44 | id = PMID 11903044}}</ref> | The '''insulin-like growth factor II (IGF-II) internal ribosome entry site''' [[IRES]] is found in the [[5' UTR]] of IGF-II leader 2 [[mRNA]]. This [[cis-regulatory element|RNA element]] allows cap-independent [[translation]] of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.<ref>{{cite journal | last = Pedersen | first = SK | coauthors = Christiansen J, Hansen TO, Larsen MR, Nielsen FC | year = 2002 | title = Human insulin-like growth factor II leader 2 mediates internal initiation of translation | journal = Biochem J | volume = 363 | pages = 37–44 | id = PMID 11903044}}</ref> | ||
== | ==References== | ||
{{reflist|1}} | {{reflist|1}} | ||
==External | ==External links== | ||
* {{Rfam|id=RF00483|name=Insulin-like growth factor II IRES}} | * {{Rfam|id=RF00483|name=Insulin-like growth factor II IRES}} | ||
[[Category:Cis-regulatory RNA elements]] | |||
{{molecular-cell-biology-stub}} | {{molecular-cell-biology-stub}} | ||
Revision as of 02:26, 16 September 2007
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The insulin-like growth factor II (IGF-II) internal ribosome entry site IRES is found in the 5' UTR of IGF-II leader 2 mRNA. This RNA element allows cap-independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.[1]
References
- ↑ Pedersen, SK; Christiansen J, Hansen TO, Larsen MR, Nielsen FC (2002). "Human insulin-like growth factor II leader 2 mediates internal initiation of translation". Biochem J 363: 37–44. PMID 11903044.
External links
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