| Insulin-like growth factor II IRES
|
|
| Type:
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Cis-reg; IRES;
|
| 2° structure:
|
Published; PubMed
|
| Seed alignment:
|
Moxon SJ
|
| Avg length:
|
118.4 nucleotides
|
| Avg identity:
|
95%
|
|
This family represents the insulin-like growth factor II (IGF-II) internal ribosome entry site (IRES) which is found in the 5' UTR of IGF-II leader 2 mRNA. This family allows cap-independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development [1].
Reference
- [1] Pedersen, SK; Christiansen J, Hansen TO, Larsen MR, Nielsen FC (2002). "Human insulin-like growth factor II leader 2 mediates internal initiation of translation". Biochem J 363: 37–44. PMID 11903044.
External link
